摘要
石蒜碱是石蒜科生物碱中非常重要的一类异喹啉生物碱衍生物, 近年来药物及有机化学工作者发现石蒜碱及其衍生物具有抗肿瘤、抗炎、抑制乙酰胆碱酯酶、抗疟疾、保护心血管等多种作用, 由于其复杂而独特的分子结构和广泛的药理活性使得科研工作者们进行了大量的全合成尝试及结构修饰等研究. 作者对石蒜碱的全合成及其结构修饰进行了综述.
Abstract：
Lycorine is a very important class of isoquinoline alkaloids of the amaryllidaceae alkaloids. In recent years, pharmaceutical and organic chemists discovered that lycorine and their derivatives have anti-tumor, anti-inflammatory, inhibiting acetylcholinesterase, anti-malarial, cardiovascular protection and other effects. Because of its complex and unique molecular structure and extensive pharmaceutical activities, lycorine has attracted considerable research effort. The recent progresses in the synthesis and structural modification of lycorine are summarized in this review.
刘颖杰, 丁泽洋, 谭冲, 袁洪亮, 季宇彬. 石蒜碱的全合成及结构修饰研究进展[J]. 有机化学, 2015, 35(5): 1009-1021
