钯催化的芳基硼酸和3-羟基丙-1-炔-1-基膦衍生物的Domino加成环合反应

A novel and efficient palladium-catalyzed domino addition–cyclization of a wide range of arylboronic acids with various 3-hydroxyprop-1-yn-1-yl phosphonates has been developed, affording a convenient and powerful tool for the preparation of valuable 1,2-oxaphospholenes with mild reaction conditions, broad substrate applicability, and good to excellent yields. Mechanistic studies revealed that the reaction might involve Michael addition and nucleophilic substitution.

Ye Lv , Gaobo Hu, Dumei Ma, Liu Liu, Yuxing Gao, and Yufen Zhao 

J. Org. Chem 2015