水相银催化的α-酮酸和肉桂酸双脱羧的交叉缩合反应：一种查尔酮的合成策略

介绍了一种通过取代α酮酸和肉桂酸温和水相条件下银催化的双脱羧交叉偶联反应制备查尔酮衍生物的反应方法，通过双脱羧形成C-C双键的方法高效实用环境友好，原料易得，为查尔酮衍生物的合成提供一种有前景的方法

Silver-Catalyzed Double-Decarboxylative Cross-Coupling of α-Keto Acids with Cinnamic Acids in Water: A Strategy for the Preparation of Chalcones

Ning Zhang , Daoshan Yang *, Wei Wei , Li Yuan , Fafa Nie , Laijin Tian , and Hua Wang *

The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong P. R. China

J. Org. Chem

A silver-catalyzed double-decarboxylative protocol has been proposed for the construction of chalcone derivatives via cascade coupling of substituted α-keto acids with cinnamic acids under the mild aqueous conditions. The developed method for constructing C–C bonds via double-decarboxylative reactions is efficient, practical, and environmentally benign by using the readily available starting materials. It should provide a promising synthesis candidate for the formation of diverse and useful chalcone derivatives in the fields of synthetic and pharmaceutical chemistry.