噻唑烷二酮对肽和蛋白质的化学修饰

2,4-噻唑烷二酮作为亲核供体，通过直接的aldol反应，在温和条件下对肽和蛋白质进行修饰，可轻易引入多种官能团，产物构型不变。

Site-Specific Chemical Modification of Peptide and Protein by Thiazolidinediones

Peng Wang , Shumei Zhang , Qiuyue Meng , Ying Liu , Luqing Shang *, and Zheng Yin *

College of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China

Org. Lett

 A direct aldol reaction employing 2,4-thiazolidinediones as nucleophilic donors was performed to modify peptides and protein under mild conditions. Various functional groups could be readily introduced into protein without conformation change.