通DDQ二氯二氰基苯醌过氧化环醚化反应合成2-（3′-吲哚基）四氢呋喃系列化合物

通过DDQ氧化 环醚化合成一系列2-（3′-吲哚基）四氢呋喃化合物，该反应在两相体系内进行，可以阻止DDQH2的还原而破坏产物

Synthesis of 2-(3′-Indolyl)tetrahydrofurans by Oxidative Cycloetherification

Rachel M. Gillard and Jonathan Sperry *

School of Chemical Sciences, University of Auckland, 23 Symonds St., Auckland, 1010, New Zealand

J. Org. Chem

A series of 2-(3′-indolyl)tetrahydrofurans have been prepared by a DDQ-mediated oxidative cycloetherification process. Performing the reaction under biphasic conditions prevents reductive cleavage of the products by the spent oxidant (DDQH2).