非芳环 烷基磺酸盐和溴代杂环参与的把烷基引入杂环的偶合反应

本方法发展了一个通过烷基磺酸盐和溴代杂环反应从而把烷基引入杂环的方法

Engaging Nonaromatic, Heterocyclic Tosylates in Reductive Cross-Coupling with Aryl and Heteroaryl Bromides

Gary A. Molander *†, Kaitlin M. Traister †, and Brian T. O’Neill ‡

† Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States

‡ Pfizer Worldwide Medicinal Chemistry, Eastern Point Road, Groton, Connecticut 06340, United States

J. Org. Chem

A method has been developed for the introduction of nonaromatic heterocyclic structures onto aryl and heteroaryl bromides using alkyl tosylates in a reductive cross-coupling manifold. This protocol offers an improvement over previous methods by utilizing alkyl tosylate coupling partners that are bench-stable, crystalline solids that can be prepared from inexpensive, commercially available alcohols.